Il-10 family members as novel responders to genotoxic stress

The study explored the role of IL-10 family members, IL-19 and IL-24, in response to genotoxic stress, revealing their upregulation in cells with high DNA damage. IL-19 was induced by ionizing radiation through ROS and JNK signaling, independent of classical SASP pathways, and regulated known SASP factors like IL-1, IL-6, and IL-8. IL-24 was upregulated in response to S-phase-specific DNA damage, dependent on p38MAPK activation, and was linked to apoptosis in a mouse pancreatic cell line. These findings highlighted the potential of targeting IL-19 and IL-24 in cancer and age-related disease treatments.