IGFBP5 Promotes Neuronal Apoptosis in a 6-OHDA-Toxicant Model of Parkinson’s Disease by Inhibiting the Sonic Hedgehog Signaling Pathway
January 2024
in “
Medical Principles and Practice
”
TLDR IGFBP5 may be a potential target for Parkinson's treatment by reducing neuron death.
The study explores the role of IGFBP5 in a 6-OHDA-toxicant model of Parkinson's Disease (PD), revealing that IGFBP5 is highly expressed in affected neurons and contributes to neuronal apoptosis by inhibiting the Sonic Hedgehog signaling pathway. Silencing IGFBP5 in cell lines and a rat model reduced neurotoxicity, promoted cell proliferation, and decreased apoptosis, suggesting neuroprotective effects. These findings indicate that IGFBP5 could be a potential therapeutic target for PD, offering a new avenue for treatment by modulating the Sonic Hedgehog pathway.
