Hypervitaminosis A

The document discusses the effects of hypervitaminosis A, highlighting symptoms observed in experimental rats and two human cases. Rats given toxic doses of vitamin A (over 15,000 units daily) experienced weight loss, hair loss, bone softening, and death within 2-4 weeks. In humans, two cases of children with excessive vitamin A intake showed symptoms like anorexia, irritability, pruritus, sparse hair, and bone sensitivity. In one case, a 14-month-old male exhibited severe pruritus, irritability, sparse hair, and bone pain, with x-rays indicating a clavicle fracture. Symptoms improved after discontinuing vitamin A, underscoring the importance of regulating vitamin A intake to prevent toxicity.