Human bone marrow mesenchymal stem cells-derived exosomes stimulate cutaneous wound healing mediates through TGF-β/Smad signaling pathway
May 2020
in “
Research Square (Research Square)
”
TLDR Exosomes from stem cells help wounds heal faster by affecting specific cell signals.
The study investigated the effects of human bone marrow mesenchymal stem cells-derived exosomes (hBM-MSCs-Ex) on cutaneous wound healing in rats, focusing on the TGF-β/Smad signaling pathway. The results showed that hBM-MSCs-Ex effectively promoted the growth of human keratinocytes and human dermal fibroblasts, accelerating wound healing. The exosomes down-regulated TGF-β1, Smad2, Smad3, and Smad4 expression, while up-regulating TGF-β3 and Smad7, suggesting that hBM-MSCs-Ex facilitated wound healing by inhibiting the TGF-β/Smad pathway. This provided a potential new therapeutic strategy for treating cutaneous wounds.
