Horn With Miliary Calcification in Squamous Cell Carcinoma

The document reported a unique case of squamous cell carcinoma (SCC) with a cutaneous horn displaying miliary calcification, which had not been previously documented. The tumor, found on the foot of an elderly woman, was a well-differentiated SCC with a 1.6 cm wide plaque and showed features such as acanthosis and adenoid characteristics. The study highlighted the presence of microcalcifications in corneocytes, unrelated to mucin pools, suggesting a potential role of calcium-binding proteins in the calcification process. The findings indicated that differentiated keratinocytes might express calcium-binding proteins like calmodulin and annexins, which could contribute to the pathogenesis of dystrophic calcification in skin tumors. The study emphasized the need for further research on calcium-binding protein expression in skin tumors to better understand this phenomenon.