DYS459, DYS391, DYS388, And DYS19 Genetic Loci Have High Allelic Frequency In Patients With Prostate Cancer

    August 2015 in “ International Journal of Genetics and Molecular Biology ”
    Khaleel Shareef Hasanain, Jameel Ibraheem Noran, Hadi Hameed Imad, Abdulhasan Kareem Muhanned
    TLDR Certain genetic markers may increase or decrease prostate cancer risk.
    The study investigated the allele frequencies of 12 Y-chromosome short tandem repeat loci in 70 Iraqi males, both prostate cancer patients and controls, to assess their role in prostate cancer susceptibility. It found that alleles 10 of DYS391 and 9 of DYS459 were more common in patients, suggesting these alleles may increase susceptibility to prostate cancer. Conversely, alleles 17 of DYS456 and DYS19 appeared to confer resistance. The findings indicated that these genetic loci could potentially be used for screening and predicting prostate cancer risk in the Iraqi population.
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