Hepatitis C virus: host, environmental and viral factors promoting spontaneous clearance

    September 2020 in “ Journal of Mind and Medical Sciences ”
    Sergiu Micu, Marilena Musat, Andrada Dumitru, Dan Nicolae Păduraru, Anca Rogoveanu, Anca Silvia Dumitriu, Stana Păunica, Cristian Bălălău, Roxana Popoiag
    TLDR Hepatitis C can clear naturally in some people due to strong immune response, genetics, and limited exposure.
    The paper reviewed the spontaneous clearance of the Hepatitis C virus (HCV), which occurred in about 20-30% of cases without treatment. It found that a competent immune response, linked to IL-28B genetic polymorphism, female gender, and young age, was crucial for virus elimination. Environmental factors like limited viral exposure also played a significant role. The study noted that these factors worked together to promote clearance, although the exact mechanisms were not fully understood. Factors such as the IL-28B CC genetic variant, certain ethnicities, jaundice history, and acute superinfection with other hepatitis viruses were highlighted as influential in this process.
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