Gene profile analysis of colorectal cancer cell lines by cDNA macroarray
May 2007
in “
Oncology Reports
”
TLDR Colorectal cancer's ability to spread is due to changes in many genes, not just one.
The study analyzed gene expression profiles in a rat model of metastatic colorectal cancer to understand mechanisms of invasion and metastasis. It found that metastasising ability increased with successive cell line generations without significant changes in proliferation ability. Key findings included increased expression of integrin beta4, gamma-catenin, Smad 7, Bax, Bcl-2, c-fos, TGF-alpha, TGF-beta, PDGFb, Cdk4, and Rho B, while Rho GDIbeta and Gelsolin expression decreased. The study concluded that high metastasising ability resulted from accumulated changes in multiple gene expressions rather than a single gene alteration.
