GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types

The study "GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types" used Gas Chromatography-Time of Flight/Mass Spectrometry (GC-TOF/MS) to analyze the metabolic differences between volar (palmoplantar) and non-volar (dorsal) skin in mice. The researchers identified 96 metabolites, with 50 showing significant differences between the two skin types. The study found distinct metabolite profiles in volar and non-volar skin, with significant differences in amino acid metabolism, sugar metabolism, and nucleotide metabolism. These differences are associated with the renewal of the outer layer of skin and increased exposure to friction and stress in volar skin. This research could contribute to site-specific skin identity studies.