Functionalization of Alkenes with Difluoromethyl Nitrile Oxide to Access the Difluoromethylated Derivatives

    March 2024 in “ Organic letters ”
    Bohdan A. Chalyk, Oleksandr Zginnyk, Andrii V. Khutorianskyi, Pavel K. Mykhailiuk
    Studysummary This study reports that difluoromethyl nitrile oxide can rapidly functionalize various alkenes at room temperature, leading to products that can transform into valuable medicinal chemistry building blocks like CF2H-isoxazolines for bioactive molecule modification.
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