Formulation and evaluation of dermatological products for topical delivery / by Mahima Manian

This study, conducted under Dr. Ajay K. Banga, focused on formulating and evaluating dermatological products for effective topical drug delivery. It involved four main aims: 1) developing an anhydrous gel with sertaconazole nitrate for fungal infections, which showed effective drug levels and non-irritation; 2) assessing menthol's skin absorption using in vitro permeation and rheological analysis, revealing sufficient penetration and structural stability; 3) formulating semi-solid vehicles with diclofenac sodium, demonstrating easy spreadability and viscoelasticity, with accurate release testing; and 4) creating a positively charged nanoemulsion for minoxidil, using iontophoresis to enhance absorption and reduce systemic uptake. The study highlighted the use of in vitro techniques for optimizing topical formulations.