Finasteride Reduces Total Cholesterol in LDLR-Deficient Mice

June 2021 in “ Current developments in nutrition ”

James McQueen, Ivan Pinos, Jaime Amengual

finasteride LDLR-deficient mice total cholesterol Western diet glucose tolerance hepatic toxicity Propecia

TLDR High doses of finasteride lower cholesterol and body weight in certain mice.

The study investigated the impact of finasteride (FIN) on cardiovascular disease risk using LDLR-deficient mice. Mice were fed a Western diet with varying doses of FIN for 12 weeks. Results showed that high doses of FIN significantly reduced total cholesterol levels (P < .0001) and body weight gain (P = .0027) without affecting glucose tolerance or causing hepatic toxicity. These findings suggested that high-dose FIN could reduce total plasma cholesterol and body weight in this mouse model.

View this study on academic.oup.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Advice on usage of german topical fin brand Fynzur 2.275mg/ml

in Finasteride 74 upvotes 5 days ago

A user is seeking advice on using a DIY solution of topical finasteride (Fynzur 2.275mg/ml) mixed with minoxidil for hair loss. They are concerned about achieving full scalp coverage and prefer using a scalp applicator over a spray.

community Topical Fin 2.5 sides but no sides on Oral, need advice?

in Finasteride 37 upvotes 1 week ago

The user discusses experiencing side effects from topical finasteride but not from oral finasteride, seeking advice on this issue. They mention a gradual increase in oral finasteride dosage with no side effects.

community Temporary alternative to finasteride?

in Finasteride 99 upvotes 1 week ago

A 23-year-old male plans to temporarily stop finasteride to donate plasma for financial reasons and seeks alternative hair loss treatments like minoxidil, ketoconazole, or RU58841 during this period. He is open to suggestions to prevent further hair loss until he can resume finasteride.

community Stacking 0.5 mg oral fin with topical fin for Enclo cycle — overkill or smart?

in Finasteride 68 upvotes 1 week ago

Combining 0.5 mg oral finasteride with topical finasteride and minoxidil during an Enclomiphene cycle may help manage increased DHT levels. Monitoring for side effects is advised.

community Sensitive liver, topical fin safe to try?

in Finasteride 98 upvotes 1 week ago

Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

community 8 months Fin + Oral Minox - still losing some hairs, normal?

in Finasteride 90 upvotes 2 weeks ago

After 8 months of using oral Minoxidil 5mg and Finasteride 1mg, the user still experiences hair loss, particularly miniaturized hairs in the mid-scalp area, along with itching. They are concerned about losing around 40 hairs daily despite treatment.

Related Research

1 / 1 results

research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.