Finasteride Reduces Total Cholesterol in LDLR-Deficient Mice

The study investigated the impact of finasteride (FIN) on cardiovascular disease risk using LDLR-deficient mice. Mice were fed a Western diet with varying doses of FIN for 12 weeks. Results showed that high doses of FIN significantly reduced total cholesterol levels (P < .0001) and body weight gain (P = .0027) without affecting glucose tolerance or causing hepatic toxicity. These findings suggested that high-dose FIN could reduce total plasma cholesterol and body weight in this mouse model.