Finasteride Reduces Total Cholesterol in LDLR-Deficient Mice

June 2021 in “ Current developments in nutrition ”

James McQueen, Ivan Pinos, Jaime Amengual

finasteride LDLR-deficient mice total cholesterol Western diet glucose tolerance hepatic toxicity Propecia

TLDR High doses of finasteride lower cholesterol and body weight in certain mice.

The study investigated the impact of finasteride (FIN) on cardiovascular disease risk using LDLR-deficient mice. Mice were fed a Western diet with varying doses of FIN for 12 weeks. Results showed that high doses of FIN significantly reduced total cholesterol levels (P < .0001) and body weight gain (P = .0027) without affecting glucose tolerance or causing hepatic toxicity. These findings suggested that high-dose FIN could reduce total plasma cholesterol and body weight in this mouse model.

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research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men

30 citations, August 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride doesn't affect hormone levels in normal men.