Extramammary Paget Disease: Failure to Respond to Topical Imiquimod 5%
August 2011
in “
Journal of the American Academy of Dermatology
”
Studysummary This study reports that two elderly Asian men with primary scrotal extramammary Paget disease showed no response to a 4- to 6-month trial of topical imiquimod 5%.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Two elderly Asian men with primary extramammary Paget disease (EMPD) involving the scrotum did not respond to a 4- to 6-month trial of topical imiquimod 5%, despite previous reports of successful treatment. The first patient, a 75-year-old Chinese man, experienced a vigorous inflammatory reaction but showed no improvement and was subsequently treated successfully with radiation therapy. The second patient, a 70-year-old Japanese man, also failed to respond to imiquimod 5% and was scheduled for radiation therapy. These cases highlight that imiquimod 5% may not be effective for all patients with scrotal EMPD.
