Expression Patterns of Hair-Related Keratins and Epithelial Keratins in Onychopapilloma: The Significance of Clarifying the Origin of Onychopapilloma

    November 2022 in “ Frontiers in Medicine ”
    Mengxi Liu, Fang Li, Xiaoqing Wang, Zhenru Liu, Hoi Shiwn Wong, Yuan Zhou, Daguang Wang
    TLDR Onychopapilloma likely originates from the nail bed, not the nail matrix.
    This study analyzed 11 cases of onychopapilloma to determine its origin by examining the expression patterns of hair-related and epithelial keratins. The results indicated that onychopapilloma likely originates from the nail bed rather than the nail matrix, as evidenced by the positive expression of HK31 and nail bed-related keratins (HK75, K6/K16) and the absence of hair-related keratins (HK34, HK85, HK86) in the nail bed. These findings provide insights into differentiating onychopapilloma from other nail bed tumors, highlighting the significance of the nail bed epithelium in its development.
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