Identification of Established Drugs for Contemporary Indications: A Hospital-Based Study

    A. Sai Keshava Reddy, Madhan Mohan Immadi, Sree Dharani Nese, Aswini Ubbala, Umesh Kumar, R. E. Ugandar
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    Studysummary In this cross-sectional study at a hospital in Nandyala, researchers identified nine drugs with potential new uses, noting that Aspirin and Dapagliflozin were most frequently repurposed, and observed changes in indications, dosage, and frequency, suggesting further clinical validation is needed for safety and efficacy.
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    This study conducted at Santhiram Medical College and General Hospital analyzed 157 case files to explore drug repurposing, identifying nine drugs with new therapeutic indications. Aspirin and Dapagliflozin were the most frequently identified, with notable changes in drug categories, dosage, and frequency observed for several drugs, including Atorvastatin and Gabapentin. The study underscores the potential of drug repurposing as a cost-effective strategy, highlighting the need for further clinical validation to ensure safety and efficacy, thereby benefiting healthcare systems and patients.
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