Epithelial Growth by Rat Vibrissae Follicles In Vitro Requires Mesenchymal Contact via Native Extracellular Matrix
August 1990
in “
Journal of Investigative Dermatology
”
Research cited in this study
5 / 5 results
research Minoxidil Stimulates Mouse Vibrissae Follicles in Organ Culture
Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.
research Cultivation of Murine Hair Follicles as Organoids in a Collagen Matrix
research Rat Hair Follicle Dermal Papillae Have an Extracellular Matrix Containing Basement Membrane Components
research Expression of basement membrane components through morphological changes in the hair growth cycle
research Immunohistochemical Localization of Basement Membrane Components During Hair Follicle Morphogenesis
Related Research
2 / 2 results
research Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells
Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.
research Experimental Approaches for the Reconstitution of Hair in vitro
The study explored the role of dermal papillae in hair growth using in vitro cultures. It was found that outer root sheath cells (ORSCs) grew more actively when cultured with dermal papillae, suggesting the presence of papilla-derived factors that stimulate ORSC growth. Additionally, epithelial cells from the bulb matrix grew towards implanted dermal papillae, indicating that dermal papillae might produce factors that attract these cells. When the dermal papilla remained attached to the hair bulb matrix, hair and follicle elongation continued for over a week. However, detachment or damage to the papilla-matrix junction suppressed hair and follicle growth, highlighting the importance of this attachment for normal development.