Enzyme-triggered on-demand release of a H<sub>2</sub>O<sub>2</sub>-self-supplying CuO<sub>2</sub>@Fe<sub>3</sub>O<sub>4</sub> nanoagent for enhanced chemodyamic antimicrobial therapy and wound healing

    January 2024 in “ Journal of Materials Chemistry B ”
    Sijie Zhang, Sameer Hussain, Yuhai Tang, Kai‐Li Wang, Xingyan Wang, Long Zhang, Yuheng Liao, Chen Wang, Yi Hao, Ruixia Gao
    This study presents an advanced nano-antimicrobial system, HA-CP@Fe<sub>3</sub>O<sub>4</sub>, which enhances chemodynamic therapy (CDT) by stabilizing CuO<sub>2</sub> nanomaterials with a hyaluronic acid (HA) coating. This system is enzyme-responsive, releasing CuO<sub>2</sub>@Fe<sub>3</sub>O<sub>4</sub> in the presence of hyaluronidase-secreting bacteria, leading to the self-supply of H<sub>2</sub>O<sub>2</sub> and generation of reactive oxygen species (ROS) for effective antimicrobial activity. The magnetic property of Fe<sub>3</sub>O<sub>4</sub> allows targeted delivery to infection sites. Both in vitro and in vivo tests confirmed its excellent antimicrobial capabilities at low concentrations, biocompatibility, and ability to accelerate wound healing, offering a promising approach for targeted CDT.
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