Emerging Roles for Ion Channels in Ovarian Cancer: Pathomechanisms and Pharmacological Treatment

The document reviewed the role of ion channels in ovarian cancer (OC), highlighting their involvement in cancer proliferation, invasion, and chemotherapy resistance. It was found that increased expression of voltage-gated and epithelial sodium channels contributed to OC cell proliferation and invasion. Potassium and calcium channels were critical in controlling the cell cycle and resistance to apoptosis, promoting tumor growth and recurrence. Overexpression of chloride and transient receptor potential channels supported their role in OC. The study suggested that understanding ion channel expression and function could enhance pathophysiological insights and identify potential targets for OC diagnosis and treatment.