Comparative Efficacy of Low-Dose Oral Minoxidil, Topical Minoxidil, and Platelet-Rich Plasma with Topical Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial

June 2024 in “ British Journal of Dermatology ”

P Janaani, Muthu Sendhil Kumaran, Keshavamurthy Vinay, Hitaishi Mehta, Vinod Sharma

low-dose oral minoxidil topical minoxidil platelet-rich plasma androgenetic alopecia terminal hair density vellus hair density Treg cell populations signalling molecules oral minoxidil Rogaine PRP AGA

TLDR Combining PRP with topical minoxidil is the most effective for increasing hair density in male pattern baldness.

This randomized controlled trial compared the efficacy of low-dose oral minoxidil, topical minoxidil, and platelet-rich plasma (PRP) combined with topical minoxidil in treating androgenetic alopecia (AGA) in 66 male participants. Over 32 weeks, Group 3 (PRP with topical minoxidil) showed the most significant increase in terminal hair density, while Group 1 (oral minoxidil) was more effective in reducing vellus hair density. All treatments led to a reduction in hair diameter diversity and changes in Treg cell populations and signalling molecules, with no significant differences between the groups. The study supports low-dose oral minoxidil as a viable alternative to topical minoxidil and highlights the benefits of combining PRP with topical minoxidil.

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community When are we getting a cure to hair loss?

in Chat 2 years ago

Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

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in Chat 35 upvotes 6 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

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in Treatment 6 upvotes 1 month ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community 21F AGA - 4 month hair growth progress (Minoxidil 5%, finasteride 1mg, theradome LLLT, viviscal vitamins, PRP twice)

in Progress Pictures 257 upvotes 3 years ago

A 21-year-old female shared her 4-month hair growth progress using Minoxidil 5%, finasteride 1mg, Theradome LLLT, Viviscal vitamins, and PRP treatments twice. Commenters praised her progress and discussed other treatments like microneedling, but she noted her dermatologist advised against it due to potential scalp damage.

community I cry every day, everything is very depressing

in Finasteride/Dutasteride 52 upvotes 1 month ago

A user is experiencing hair loss despite using dutasteride and oral minoxidil, feeling hopeless and considering a hair system. They are advised to try ketoconazole, seek a second opinion from a dermatologist, and consider treatments like finasteride, RU58841, and hair transplants.

community 2025 Official beginner guide for “I’m losing my hair, what can I do?”

in General 816 upvotes 8 months ago

For hair loss, start with Finasteride, Minoxidil, Ketoconazole shampoo, and Microneedling. For severe cases, consider Dutasteride, oral Minoxidil, or hair transplants.

Related Research

2 / 2 results

Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

research Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

August 2023 in “Journal of Cosmetic Dermatology”

Some plants like spinach, broccoli, and matcha may boost the effectiveness of the hair growth drug minoxidil.

research Scalp Psoriasiform Contact Dermatitis with Acute Telogen Effluvium Due to Topical Minoxidil Treatment

14 citations, January 2015 in “Skin appendage disorders”

Minoxidil treatment for hair loss can cause scalp allergy and severe hair loss.