Clinical Efficacy, Cosmetic Acceptability, and Local Tolerability of a New Formulation of Topical 5% Minoxidil Without Propylene Glycol: A 6-Month, Multicentre, Real-Life, Prospective, Assessor-Blinded Study in 196 Subjects with Hair Loss. The NOMINAL Trial

January 2021 in “ Journal of clinical & experimental dermatology research ”

Laura Alessi, Maria Stella Aloisi, Valentina Amadu, Alex Arena, Ylenia Balice, Stefania Bano, Stefania Barruscotti, Annunziata Bartolotta, Silvia Bondino, Arianna Corsini, Di Nunno, Stefania Farina, Paola Nappa, Luigi Pisano, Fabrizio Presta, Nicolo Rivetti, Elena Saccani, Marco Tomassini, Sonia Torti, Fabrizio Vaira, Giovanni Zanframundo, Mario Puviani, Klause Eisendle, Massimo Milani

minoxidil topical 5% minoxidil propylene glycol hair loss hair growth hair density hair thickness scalp irritation side effects Rogaine

TLDR The new 5% minoxidil formulation without propylene glycol effectively promotes hair growth with fewer side effects and better user satisfaction.

The "NOMINAL" trial evaluated the clinical efficacy, cosmetic acceptability, and local tolerability of a new 5% minoxidil formulation without propylene glycol over 6 months in 196 subjects with hair loss. The study found that the new formulation was effective in promoting hair growth, with significant improvements observed in hair density and thickness. Participants reported high levels of cosmetic acceptability, noting less greasiness and better overall satisfaction compared to traditional formulations. Additionally, the new formulation demonstrated good local tolerability, with fewer reports of scalp irritation and other side effects. These findings suggested that the new minoxidil formulation could be a viable alternative for individuals experiencing hair loss.

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6 / 1000+ results

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 88 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community switched from topical to oral minoxidil (topical mixed with water) 3 months ago and aside from being much easier i’ve also had much more density overall. My results aren’t even finished yet!

in Progress Pictures 2 years ago

This user discussed using oral minoxidil as a hair loss treatment, and was cautioned against mixing topical minoxidil with water and drinking it due to potential side effects and risks. Other users shared their concerns about the dangers of self-prescribing medications without consulting a doctor.

community Better then Minoxidil( at least for me and my family)

in Treatment 42 upvotes 10 months ago

Capronium Chloride and Trichoxidil are suggested as better alternatives to Minoxidil for hair growth without heart side effects. The Japanese Dermatological Association recommends topical Minoxidil over Capronium Chloride.

community Minoxidil seems logistically impossible and impractical to use

in Minoxidil 136 upvotes 1 year ago

The post discusses concerns about the practicality of using Minoxidil foam for hair loss, including the frequency of application, preparation, coverage area, and drying time. Responses suggest that missing a dose isn't detrimental, it can be applied once a day, it works on all hair areas, and it doesn't need to be perfectly dry before application.

community Topical Fin Vs Oral Fin. Which is better and has less sides?

in Finasteride/Dutasteride 45 upvotes 1 year ago

Comparing the effectiveness and side effects of topical finasteride versus oral finasteride, with people sharing their experiences using both treatments to manage hair loss.

community 2.5 years Minoxidil and HRT, CPA->Lupron +Minox 5%

in Transgender 611 upvotes 1 month ago

The user experienced significant hair regrowth after 2.5 years of using Minoxidil 5% and hormone replacement therapy (HRT) with Lupron, despite initial scalp irritation. Finasteride was ineffective for them.

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