Clinical Efficacy, Cosmetic Acceptability, and Local Tolerability of a New Formulation of Topical 5% Minoxidil Without Propylene Glycol: A 6-Month, Multicentre, Real-Life, Prospective, Assessor-Blinded Study in 196 Subjects with Hair Loss. The NOMINAL Trial

    January 2021 in “ Journal of clinical & experimental dermatology research ”
    Laura Alessi, Maria Stella Aloisi, Valentina Amadu, Alex Arena, Ylenia Balice, Stefania Bano, Stefania Barruscotti, Annunziata Bartolotta, Silvia Bondino, Arianna Corsini, Di Nunno, Stefania Farina, Paola Nappa, Luigi Pisano, Fabrizio Presta, Nicolo Rivetti, Elena Saccani, Marco Tomassini, Sonia Torti, Fabrizio Vaira, Giovanni Zanframundo, Mario Puviani, Klause Eisendle, Massimo Milani
    From the encyclopedia
    Minoxidil →

    An essential vasodilator with some anti-androgenic effects

    propylene glycol →
    Studysummary This study found that a new propylene glycol-free 5% minoxidil lotion demonstrated good clinical efficacy and very good cosmetic acceptability and tolerability after six months of use in patients with androgenetic alopecia, showing results comparable to traditional formulations containing propylene glycol. Our plain-language summary of this paper — not a Tressless recommendation.
    The "NOMINAL" trial evaluated the clinical efficacy, cosmetic acceptability, and local tolerability of a new 5% minoxidil formulation without propylene glycol over 6 months in 196 subjects with hair loss. The study found that the new formulation was effective in promoting hair growth, with significant improvements observed in hair density and thickness. Participants reported high levels of cosmetic acceptability, noting less greasiness and better overall satisfaction compared to traditional formulations. Additionally, the new formulation demonstrated good local tolerability, with fewer reports of scalp irritation and other side effects. These findings suggested that the new minoxidil formulation could be a viable alternative for individuals experiencing hair loss.
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