Effects of the bovine slick mutation on heat stress responses and hair growth in mice

The study investigated the effects of the bovine slick mutation, which truncates the prolactin receptor, on heat stress responses and hair growth in genetically modified mice. Mice were exposed to increasing temperatures, and various parameters such as feed and water disappearance, tail temperature, and nest scores were measured. The results indicated that the mutation improved heat stress responses, as evidenced by differences in feed and water consumption and tail temperature, particularly at higher temperatures. However, no hair phenotype was observed, suggesting that the mutation's effects on thermal tolerance were not due to changes in hair but likely through another mechanism. Additionally, sex influenced hair regrowth, with males showing faster regrowth than females.