Effect of transcranial electrical stimulation on markers of immunosuppression in patients with COVID-19

The study investigated the effect of transcranial electrical stimulation on immunosuppression markers in 34 COVID-19 patients with mild to moderate symptoms. Patients were divided into two groups: 19 received standard treatment, while 15 received additional transcranial electrical stimulation. Both groups showed significant decreases in interleukin-10 levels and the interleukin-10/lymphocyte ratio by the end of the first week. However, the group receiving transcranial electrical stimulation exhibited a trend towards a more pronounced reduction in interleukin-10 (21.4% decrease, p=0.08) and the interleukin-10/lymphocyte ratio (41.5% decrease, p=0.1). These findings suggest that transcranial electrical stimulation may influence immunosuppression mechanisms in COVID-19, warranting further research.