Effect of Estradiol Locally Applied to Abnormal Skin

The document discusses the absorption and effects of natural and artificial folliculoids, such as estradiol, when applied to the skin. Research has shown that these compounds can cause estrous-like changes in the internal sex organs of mice. While there have been claims of folliculoids acting as carcinogens, no studies have successfully induced cancerous changes in the skin through their application. However, local effects such as cutaneous hyperemia and changes in hair follicles and the cornified layer have been observed in rats.