Does Inhibition of Aldose Reductase Contribute to the Anti-Inflammatory Action of Setipiprant?

The study from 2017 investigated setipiprant's potential mechanism of action and found that it inhibits aldose reductase, an enzyme involved in inflammation. This inhibition was demonstrated through spectrophotometric assays and molecular modeling, which showed setipiprant's interaction with the enzyme's inhibitor binding site. The findings suggest that aldose reductase inhibition could contribute to setipiprant's anti-inflammatory effects, which may be beneficial for treating conditions like asthma and androgenic alopecia. However, the study was based on biochemical assays and molecular modeling, and did not involve human or animal subjects, indicating that further experimental research is needed to validate these results.