Development and Evaluation of a Fish Skin-Derived Acellular Dermal Matrix for Diabetic Wound Healing: In Vitro and In Vivo Assessment

The study developed a fish skin-derived acellular dermal matrix (FSADM) from yellow fin tuna for diabetic wound healing, demonstrating preserved collagen structure and excellent biocompatibility both in vitro with L929 fibroblasts and in vivo in Sprague-Dawley rats. In a diabetic rat model, FSADM-treated wounds closed significantly faster than those treated with commercial alternatives, achieving 100% closure by day 21. Histological analysis showed enhanced epithelialization, hair follicle formation, and angiogenesis in FSADM-treated wounds. The study concludes that FSADM is a promising biomaterial for diabetic wound care, though further clinical validation is needed.