Cytotoxic Potential of Mangifera indica L var Arumanis Rind Extract and Fraction Against T47D Cells with Microtetrazolium (MTT) Method

The study investigated the cytotoxic potential of arumanis mango rind extract and its fractions against T47D breast cancer cells using the Microtetrazolium (MTT) method. The research utilized various concentrations of ethanol extract, n-hexane, ethyl acetate, and n-butanol fractions, comparing their effects to doxorubicin. Results showed that the ethanol extract and ethyl acetate fraction had significant cytotoxic effects, with IC50 values of 32.21 µg/ml and 90.57 µg/ml, respectively, compared to doxorubicin's IC50 of 1.44 µg/ml. The study concluded that arumanis mango rind extract and fractions exhibit cytotoxic potential, with the ethanol extract and ethyl acetate fraction showing the most promise alongside doxorubicin.