Curly: A New Hair Defect Mutation in the SELH/Bc Mouse Strain

    November 2015
    Lydia Taylor
    TLDR The curly mutation in SELH/Bc mice affects hair and may help study human genetic disorders.
    The study investigated the curly mutation (cur), an autosomal recessive mutation in the SELH/Bc mouse strain, characterized by a waved and ruffled coat, crimped vibrissae, and potential hair loss. The mutation was mapped to chromosome 11, within a region containing several dominant hair defect mutations and keratin genes. Initial mapping using 32 homozygous curly F2 mice narrowed the mutation to a 6 cM interval, while further refinement with 71 F2 mice from a second outcross reduced it to a 4 cM region. The study highlighted the SELH strain's elevated mutation rate and its potential as a model for human genetic disorders.
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