Comparison of COVID-19 Vaccination with Influenza Vaccination in Korean Patients with Systemic Lupus Erythematosus: Perception, Adverse Events, and Flares from the CIVIL Study

July 2023

Seonghoon Park, Seung Cheol Shim, Jisoo Lee, Young Ho Lee, Seung‐Ki Kwok, Yong‐Gil Kim, Yong‐Beom Park, Sung‐Hwan Park, Sang‐Cheol Bae, Chang‐Hee Suh, Yoon-Kyung Sung, Shin‐Seok Lee, Chang‐Keun Lee, Hye‐Soon Lee, Seung Min Jung, Hoon‐Suk Cha

systemic lupus erythematosus SLE COVID-19 vaccine influenza vaccine lupus flare adverse events flu shot

TLDR The COVID-19 vaccine is viewed more negatively and causes more side effects than the flu vaccine in Korean patients with lupus.

The CIVIL study compared the perception and safety of COVID-19 and influenza vaccines in 207 Korean patients with systemic lupus erythematosus (SLE). The study found that 77.7% of SLE patients completed the COVID-19 vaccine, while 87.6% completed the influenza vaccine. Fear of lupus flare and side effects were significant reasons for vaccine hesitancy, especially for the COVID-19 vaccine. Adverse events were more common with the COVID-19 vaccine (65.8%) compared to the influenza vaccine (12.4%), with 10.3% of COVID-19 vaccinated patients experiencing lupus flares. The study concluded that the COVID-19 vaccine has a worse perception and higher adverse events compared to the influenza vaccine in this patient group.

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