Rare and Common Manifestations of COVID-19 in Children

The document discusses the various skin manifestations of COVID-19 in children, including chilblain-like lesions (CLLs), which are often accompanied by itch and pain, and are mostly observed in patients without severe COVID-19 organ manifestations. The document also mentions other skin phenomena resembling post-infective phenomena observed in other viral infections. The role of the type I interferon (IFN-I) pathway in the induction of CLLs is suggested, but the definite causal relation with COVID-19 remains uncertain. The study involved 198 patients and found that 70% of all the lesions reported were CLLs, mainly present in adolescents. Other manifestations included a varicella-like rash, papulosquamous rashes, and PLEVA-like dermatitis. The document concludes that further studies are required to confirm these findings and understand these clinical aspects, including recurrence phenomena and age-related distribution.