Rare and Common Manifestations of COVID-19 in Children

    February 2022 in “ JEADV Clinical Practice
    Cristiana Colonna, Lucia Restano, Nicola Adriano Monzani, Martina Zussino, Alessandra Ponziani, Stefano Cambiaghi, Riccardo Cavalli
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    Studysummary This review discusses the diverse range of skin manifestations in children with COVID-19 and highlights the complexity of clinical assessment due to varied presentations; it reports no new clinical findings.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document discusses the various skin manifestations of COVID-19 in children, including chilblain-like lesions (CLLs), which are often accompanied by itch and pain, and are mostly observed in patients without severe COVID-19 organ manifestations. The document also mentions other skin phenomena resembling post-infective phenomena observed in other viral infections. The role of the type I interferon (IFN-I) pathway in the induction of CLLs is suggested, but the definite causal relation with COVID-19 remains uncertain. The study involved 198 patients and found that 70% of all the lesions reported were CLLs, mainly present in adolescents. Other manifestations included a varicella-like rash, papulosquamous rashes, and PLEVA-like dermatitis. The document concludes that further studies are required to confirm these findings and understand these clinical aspects, including recurrence phenomena and age-related distribution.
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