TLDR Larger nail cavity sizes suggest benign tumors, while smaller ones may need further biopsy to rule out cancer.
This study compared the clinical and histopathologic characteristics of onychocytic matricomas (OCMs) and onychomatricomas (OMs) through 4 cases of OCMs and 5 cases of OMs. Both types of tumors exhibited a thickened nail plate with a longitudinal band pattern, but OCMs showed a V-shaped keratogenous epithelial tumor with a papillomatous growth pattern, while OMs displayed a panonychoma fibropapilliferum pattern. The study highlighted the importance of nail clipping in diagnosing onychomatrical tumors, suggesting that larger cavities in the nail plate (over 0.15 mm) could indicate a benign growth, potentially avoiding unnecessary excisional procedures. Conversely, smaller cavities (under 0.10 mm) should lead to a biopsy to exclude malignancy.
39 citations
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February 2011 in “American Journal of Dermatopathology” Onychomatricoma is a unique nail tumor that mimics the entire nail unit and is not related to other hair-related tumors.
1398 citations
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May 2008 in “Histochemistry and Cell Biology” Keratins are crucial for cell stability, wound healing, and cancer diagnosis.
110 citations
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August 2004 in “British Journal of Dermatology” The ventral matrix is the main source of the nail plate.
119 citations
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January 2000 in “British Journal of Dermatology” Different parts of the nail express different keratins, showing unique patterns of differentiation.
3 citations
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November 2022 in “Frontiers in Medicine” Onychopapilloma likely originates from the nail bed, not the nail matrix.
16 citations
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July 2021 in “Histopathology” New markers and pathways have been found in skin tumors, helping better understand and diagnose them.
8 citations
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May 2021 in “Journal of the European Academy of Dermatology and Venereology” A COVID-19 patient had unusual nail discoloration and nail separation possibly due to the virus's effects on small blood vessels.
65 citations
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January 2013 in “Cochrane library” Some systemic treatments work for nail psoriasis but can have serious side effects.
36 citations
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June 2018 in “Journal of The American Academy of Dermatology” Dermoscopy is useful for diagnosing various skin, hair, and nail disorders and can reduce the need for biopsies.