Comments on 'Maternal–Fetal Safety Evaluation of an Aqueous Extract of Casearia Sylvestris Leaves in Rats' (Nagaoka et al., 2023)

The correspondence by L. David Wise and John M. DeSesso comments on the study by Nagaoka et al. (2023) regarding the maternal-fetal safety of an aqueous extract of Casearia sylvestris (AECS) leaves in rats. The authors discuss the methodology and findings of the original study, emphasizing the importance of historical control data and proper interpretation of toxicological significance. They highlight the need for careful consideration of factors such as progeny body weights and anogenital distance when evaluating developmental toxicity. No new data were created or analyzed in this commentary.