Combating Dread Shed: The Impact of Overlapping Topical and Oral Minoxidil on Temporary Hair Shedding During Oral Minoxidil Initiation

    March 2024 in “ JAAD International ”
    Ambika Nohria, Deesha Desai, Magdalena Sikora, Soutrik Mandal, Jerry Shapiro, Kristen Lo Sicco
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    TLDR Using both topical and oral minoxidil doesn't significantly reduce temporary hair shedding.
    The study examined whether continuing topical minoxidil while starting low-dose oral minoxidil (LDOM) reduces temporary hair shedding, known as "dread shed." A review of 115 patients at NYU Langone Health found that 5.2% experienced dread shed, with no significant difference between those who overlapped therapies and those who did not. The study concluded that overlapping topical and oral minoxidil does not significantly impact the occurrence of dread shed, indicating that continuing topical minoxidil during LDOM initiation may not be clinically beneficial. Further research with larger samples is needed to address this side effect.
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