The Role of Cochlea Extracellular Matrix in Age-Related Hearing Loss

The study highlights the critical role of the cochlea's extracellular matrix (VSM) in age-related hearing loss (ARHL), emphasizing its importance in maintaining cochlear structure, sound signal transmission, and ionic balance. Aging leads to changes in the VSM's structure and composition, potentially contributing to pathologies like congenital hearing loss (CHD). Despite its significance, the role of VCM-associated molecules in CHD development is not well understood, indicating a need for further research. The study involved a literature review using databases like PubMed and Google Scholar to evaluate mechanisms of ARHL and identify knowledge gaps.