A Global Analysis of CNVs in Chinese Indigenous Fine-Wool Sheep Populations Using Whole-Genome Resequencing

    November 2020
    Chao Yuan, Zengkui Lu, Tingting Guo, Yaojing Yue, Xijun Wang, Tianxiang Wang, Yajun Zhang, Fujun Hou, Chune Niu, Xiaopin Sun, Hongchang Zhao, Shaohua Zhu, Jianbin Liu, Bohui Yang
    TLDR The study found genetic variations in sheep that affect traits like milk production, growth, and health.
    This study analyzed the genome-wide distribution of copy number variations (CNVs) in 32 fine-wool sheep from three breeds using whole-genome resequencing. A total of 1,747,604 CNVs were detected, resulting in 7,228 CNV regions (CNVRs) that covered 2.17% of the sheep reference genome. Deletion events were more common than duplication events. The CNVRs were associated with genes involved in sensory perception, nutrient metabolism, and growth processes, and 1,855 CNVRs were linked to 166 quantitative trait loci (QTLs) related to milk, carcass, and health traits. The study also found that the RXFP2 gene was significantly affected by selection in horned and polled sheep groups. This research provided a valuable genetic variation resource for sheep genome studies and contributed to understanding complex traits in sheep.
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