Clinical Snippets
June 2005
in “
Journal of Investigative Dermatology
”
TLDR A bull with a gene mutation was asymptomatic, synthetic retinoids cause hair loss, and new therapeutic targets were identified for skin diseases.
The document reported on several dermatological studies. One study by Ford and colleagues in New Zealand found that a bull with a keratin 5 gene mutation, similar to human epidermolysis bullosa (EB), was asymptomatic due to being mosaic, explaining the fewer affected offspring. This bull's calves could serve as models for EB. Another study by Foitzik and colleagues showed that synthetic retinoids, while effective for skin conditions, caused hair loss by upregulating TGF-ß2, suggesting that TGF-ß2 antagonists could prevent this side effect. Additional studies explored the role of CD34+ cells in herpes-associated erythema multiforme, the involvement of CCR4 and TARC/CCL17 in cutaneous lupus erythematosus, and the suppression of ATP2C1 gene expression in Hailey-Hailey disease, indicating potential therapeutic targets.
