Chemotherapy-Related Adverse Effects with Anthracycline and Taxane-Containing Regimens in Patients with Localized Breast Cancer: A Descriptive Study

January 2024 in “ BMC Cancer ”

Farah Choulli, Hassan Abdelilah Tafenzi, Faiçal El Hattimy, M. Choulli, Rhizlane Belbaraka

alopecia dermatological toxicity skin reactions nail toxicity

TLDR Anthracycline and taxane chemotherapy cause significant side effects like fatigue, vomiting, nausea, nerve damage, joint pain, and hair loss in breast cancer patients.

This study examined the short-term adverse effects of anthracycline and taxane chemotherapy regimens in 122 Moroccan women with localized breast cancer. It found that anthracyclines were linked to higher rates of asthenia (79.5%), vomiting (87.7%), and nausea (82.8%), while taxanes were associated with increased neurotoxicity and arthromyalgia (74.6% and 62.3%). Both regimens resulted in high rates of alopecia (96.7% with anthracyclines and 95.1% with taxanes). The study emphasizes the need for effective management of these side effects and suggests developing a mobile health app for better patient follow-up. Further research is recommended to expand the patient population and include toxicity grading.

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