Using a Capture–Recapture Method to Assess the Frequency of Adverse Drug Reactions in a French University Hospital
February 2006
in “
British Journal of Clinical Pharmacology
”
TLDR The study found that combining different databases gives a better estimate of drug side effects in hospitals.
In 2006, researchers conducted a study to estimate the incidence of serious adverse drug reactions (ADRs) in the medical wards of a French university hospital. They used a capture-recapture method, analyzing data from the Programme de Medicalization des Systemes d'Information (PMSI) and the French Pharmacovigilance Database. The study found 274 ADRs from PMSI and 151 ADRs from the Pharmacovigilance Database, with 52 ADRs common to both. The estimated total number of serious ADRs was 796, which represented 2.9% of inpatients. The study revealed that ADR reporting is incomplete and suggested that combining data from multiple databases could provide a more accurate picture of ADRs in hospital settings. However, it recommended further research before this method is used routinely.
