The Secret of C3 Glomerulopathy in a Lupus Patient

    May 2025 in “ The Journal of Rheumatology ”
    Rabahi Ramzi, Zitouni Mahdia, Djama Med--Lyes, M. Boucelma
    TLDR Atypical symptoms in lupus can indicate different kidney issues.
    This case report discusses a 48-year-old man with systemic lupus erythematosus (SLE) who presented with persistent proteinuria and hematuria. A renal biopsy revealed isolated C3 glomerulopathy with active lesions, and further investigation showed a low C3 complement level and a monoclonal IgG Lambda component. Despite normal glomerular filtration rate, these findings suggest a diagnosis of monoclonal gammopathy of renal significance rather than typical lupus nephropathy. The report emphasizes the importance of considering atypical presentations in SLE patients to expand diagnostic possibilities.
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