Bioengineered Exosomal Hair Growth Factors Complex in Upregulating HFDPCs, Downregulating IL-6, IL-1β in Hair Growth

    December 2025 in “ Plastic & Reconstructive Surgery ”
    Arundha Abrol, Garima Balpande, Mahesh Gosavi, Komal Doshi, Disha Singhal, Yuti Nakhwa, Kim Su Jung, Jung Dai Hyun
    TLDR The treatment effectively reduces hair loss and improves hair growth with minimal side effects.
    The study evaluates the Bioengineered Exosomal Hair Growth Factors Complex (BEHC™) for treating androgenetic alopecia, showing promising results. In vitro, the treatment significantly increased human follicle dermal papilla cell proliferation by 172.4% and reduced inflammatory markers IL-6 and IL-1β. In vivo, involving 85 participants, the treatment reduced hair shedding from 7.8 to 1.4 hairs and improved hair density and thickness, with effects lasting two months post-treatment. The BEHC™ is a minimally invasive and effective option for hair loss management with minimal adverse effects, representing a significant advancement in regenerative dermatology.
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