Baricitinib-Loaded Separable Microneedle Array Patch Based on Hyaluronic Acid for Alopecia Areata Therapy

    January 2025
    Da In Jeong, Song Yi Lee, Sungyun Kim, Seong Jin Jo, Haifeng Yang, Jae-hyuk You, ChaeRim Hwang, Ji Won Huh, Yeoung Eun Choi, W. S. Jo, In-Jeong Choi, Shunro Matsumoto, Seungki Baek, Woonsung Na, Jung‐Hwan Park, Hyun‐Jong Cho
    TLDR The patch effectively promotes hair growth for alopecia areata without pain.
    The study presents a novel separable microneedle array patch (S-MAP) based on hyaluronic acid for the topical delivery of baricitinib to treat alopecia areata (AA). This method aims to avoid the systemic side effects of oral administration and offers a pain-free alternative to typical intradermal injections. The baricitinib-loaded S-MAP demonstrated effective insertion in porcine and mouse skin, with significantly higher hair growth in mouse models compared to the control group (68% vs 33%, p < 0.05). These findings suggest that the baricitinib S-MAP system is an efficient and safe option for AA therapy, allowing for self-medication without pain.
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