Assessment of the Impact of Atmospheric Cold Plasma Application on Wound Healing in Streptozotocin-Induced Diabetic Rats

This study evaluated the effects of atmospheric pressure cold plasma (APCP) and plasma-activated water (PAW) on wound healing in 40 diabetic rats. The rats were divided into five groups, with different treatments applied to standardized wounds. The PAW-treated group showed the most significant reduction in wound dimensions, particularly in the early healing phase, and continued to improve at each assessment point. Histological analysis revealed increased epidermal thickness, collagen deposition, and hair follicle density, along with elevated antioxidant levels in the PAW group compared to other treatments. The study concludes that PAW is more effective than APCP and conventional dressings in promoting wound healing in diabetic rats, suggesting its potential as a therapeutic approach for diabetic wounds.