Antiviral Drugs Screening for Swine Acute Diarrhea Syndrome Coronavirus

The study screened 3,523 compounds to identify potential antiviral drugs against Swine Acute Diarrhea Syndrome Coronavirus (SADS-CoV) and found five with significant inhibitory effects: methylene blue, cepharanthine, gemcitabine, mycophenolate mofetil, and mycophenolic acid. Methylene blue and cepharanthine were particularly effective, with methylene blue inhibiting both viral entry and replication, and cepharanthine blocking viral entry. Gemcitabine, mycophenolate mofetil, and mycophenolic acid inhibited viral replication post-entry. These findings suggested that these compounds could serve as potential therapeutic agents for managing SADS-CoV infections, highlighting the need for further development of antiviral treatments.