Antioxidant and Cholinesterase Inhibitory Activity of a New Peptide From <i>Ziziphus jujuba</i> Fruits

The study investigated a new peptide, Snakin-Z, derived from Ziziphus jujuba fruits, for its potential use in treating Alzheimer's disease due to its cholinesterase inhibitory and antioxidant activities. Snakin-Z demonstrated significant inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 0.58 ± 0.08 mg/mL and 0.72 ± 0.085 mg/mL, respectively, and showed 80% enzyme inhibitory activity at 1.5 mg/mL. Additionally, it exhibited high antioxidant activity with an IC50 of 0.75 ± 0.09 mg/mL. The findings suggested that Snakin-Z could be beneficial for Alzheimer's treatment, although further in vivo research was needed to confirm its efficacy.