Angelica sinensis promotes cortical regeneration of the thymus in mice with acute thymic involution induced by short-term rapamycin treatment

The study investigates the effects of Angelica sinensis on thymic regeneration in mice with rapamycin-induced acute thymic involution. Seventy-two female BALB/c mice were divided into six groups, with Angelica sinensis administered in varying doses. Results showed that medium and large doses of Angelica sinensis significantly promoted cortical regeneration, enhanced thymic epithelial cell density, and improved thymocyte development. It also reduced pro-inflammatory factors and supported peripheral T-cell homeostasis. Mechanistically, Angelica sinensis activated the Wnt/CTNNB1/Foxn1 signaling pathway, aiding in thymic repair and hematopoietic stem cell homing. These findings suggest Angelica sinensis may counteract immune aging by promoting thymic recovery.