Analysis and Clinical Determinants of Post-Covid-19 Syndrome in the Lombardy Region: Evidence From a Longitudinal Cohort Study

    February 2024 in “ BMJ Open ”
    Fabio Borgonovo, Pietro Giorgio Lovaglio, Chiara Mariani, Paolo Berta, Maria Vittoria Cossu, Giuliano Rizzardini, Giorgio Vittadini, Amedeo Capetti
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    TLDR The study concluded that different treatments reduced post-COVID symptoms over time and that factors like age, severity, and comorbidities affect symptom risk.
    The longitudinal cohort study conducted at Luigi Sacco University Hospital in Milan, Italy, analyzed post-COVID-19 syndrome in 575 patients from the first wave and 793 patients from the second wave of the pandemic. The study identified three main post-COVID-19 symptoms: neurological, sensorial, and physical. It found significant associations between these symptoms and patients' comorbidities, as well as the medications used during the acute phase of COVID-19. ACE inhibitors and inhaled steroids increased the incidence of neurological symptoms, while age, COVID-19 severity, number of comorbidities, and certain diseases increased the risk of physical symptoms. Being male was the only protective factor identified in both waves. The incidence of post-COVID symptoms dropped dramatically between the two waves, likely due to different therapeutic approaches. The study concluded that these findings could guide future medical choices.
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