Study of Alpha Mangostin as a Chemoprotective Agent for Breast Cancer via Activation of the p53 Pathway

The study investigated alpha mangostin, an extract from Garcinia mangostana, as a potential chemoprotective agent for breast cancer by activating the p53 pathway. The research focused on MCF10A breast cancer cells, demonstrating that alpha mangostin protected wild-type cells from the chemotherapeutic agent paclitaxel by inducing cell cycle arrest. However, this protective effect was not observed in p53 knockout cells, where cell viability decreased. These findings suggested that alpha mangostin could be effective in targeting the p53 pathway for chemoprotection in wild-type cells, highlighting the need for further research on its use.