Albendazole treatment of echinococcosis in humans: Effects on microsomal metabolism and drug tolerance
TLDR Albendazole treatment for echinococcosis can cause serious side effects and requires close monitoring.
The study on albendazole treatment for echinococcosis in 20 patients found that the drug inhibited microsomal enzyme function and induced its own metabolism, leading to decreased plasma levels of albendazole sulfoxide in some patients. Significant side effects included hepatotoxicity, neutropenia, and alopecia, with 50% of patients experiencing hair loss and one case of total alopecia. The findings underscored the importance of close therapeutic monitoring due to the substantial incidence of adverse effects.
