Advances in Lipid Nanoparticle-Based Disease Treatment

    February 2025 in “ ChemMedChem ”
    Yujie Zhou, Qiqi Ge, Xin Wang, Yuhui Wang, Qianqian Sun, Jianhao Wang, Tie Yang, Cheng Wang
    TLDR Lipid nanoparticles improve treatment delivery and are key to future therapies, but challenges in manufacturing and safety remain.
    Lipid nanoparticles (LNPs) have become a transformative tool for targeted therapeutic delivery, significantly improving treatment efficacy and safety across various diseases. This review discusses the evolution of lipid-based nanotechnology from the 1960s to address issues like poor bioavailability and instability. LNPs have shown promise in cancer therapy, gene therapy, infectious disease management, and more, particularly in delivering mRNA and siRNA for genetic interventions such as RNA interference and CRISPR-Cas9. Despite their potential, challenges remain in large-scale manufacturing, stability, and safety evaluations. Future research should focus on optimizing formulations, exploring combinations with existing therapies, and expanding treatable diseases, with LNPs expected to play a central role in next-generation therapeutics.
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