Adenosine and Its Receptors in the Pathogenesis and Treatment of Inflammatory Skin Diseases

The review examines the role of adenosine and its receptors in inflammatory skin diseases, emphasizing their potential as therapeutic targets. Adenosine interacts with four receptors (A1, A2A, A2B, A3) to regulate immune responses and cellular processes. A2A agonists have shown promise in reducing inflammation and remodeling the epidermis, while A3 agonists are under clinical investigation. The review highlights adenosine's dual role in promoting keratinocyte proliferation and exerting immunosuppressive effects, particularly in psoriasis. It underscores the need for further research to optimize adenosine receptor-targeted therapies, considering their potential for fewer side effects and synergistic effects with conventional treatments.