Abstract 5202: Bone marrow-derived epithelial cells contribute to chronic skin inflammation and skin tumor formation in the mouse

The study demonstrated that bone marrow-derived cells (BMDCs) contributed to skin tumor development and chronic skin inflammation in a mouse model. BMDCs were identified as a source of epithelial cells in 37.78% of papilloma samples and 53.06% of ulcer-associated dysplastic skin samples. These cells were primarily located in the basal epithelium and were highly proliferative, as indicated by BrdU incorporation and Ki67 expression. The findings suggested that BMDCs played a significant role in the formation of epithelial cells in damaged skin lesions, including papillomas and ulcers, highlighting their potential involvement in skin tumorigenesis.